Generic competition and product recalls. Patent expiry and intellectual property protection. Legal challenges and research scandals. Biogenerics and large molecule therapeutics. Cellular mechanisms of disease. Unmet needs. Government purchasing policies and insurance cover. Online pharmacy price pressures. Search for new blockbusters. Chronic disease and orphan therapies. Rheumatoid and asthma. Antibiotics and multiple resistance problems. Search for powerful antiviral therapy. Future health funding and ageing populations. Contrast with emerging nations. Treatment access and justice issues. Pharmacogenomics and gene prophecy. Ethical issues. HIV and AIDS.